#Siberian mouse meaning skin
We also found 18 immune and skin genes that were shared between humans and dogs, which we think represents inflammation in environmentally-triggered DLE (as opposed to induced DLE).
#Siberian mouse meaning drivers
We hypothesize that these 12 immune genes are strong drivers of DLE. One of our top gene hits was a chemokine called CXCL10, which we have been studying under a research grant award through the Lupus Research Alliance. We found 12 immune genes that were highly conserved (meaning the same) in skin samples from humans, dogs and mice. This approach is known as "comparative immunology", meaning comparing immune responses across different organisms, which can help researchers identify important signals in the presence of "noisy" data. We also compared these samples, which occurred spontaneously, to an inducible mouse model of DLE and to a previously published dataset from human DLE skin. We collaborated with veterinarians at Tufts Cummings School to examine leftover material from skin biopsies taken to diagnose DLE in pet dogs to better understand what drives disease in both human and veterinary patients. Genetics also plays a role, and certain dog breeds are more likely to develop DLE, including German Shepherds, Siberian Husky, Chow Chows, Brittany Spaniels, Shetland Sheepdogs, and Alaskan Malamutes. Environmental factors such as ultraviolet (UV) light and exposure to cigarette smoke appears to trigger or worsen DLE. DLE can also cause the loss of skin pigmentation in the affected area.ĭLE happens when the body’s immune system attacks the body and kills a layer of cells within the skin. When dogs develop DLE, it causes them to develop crusting and scabbing of the skin, and hair loss, usually starting around the nose. Discoid lupus erythematosus (DLE) is the most common type of cutaneous (skin) lupus in dogs. Lupus can affect not only humans, but dogs as well. The inflammation caused by lupus can affect many different areas in the body, including the skin, joints, kidneys, blood cells, brain, heart, and lungs. Lupus is an autoimmune disease that happens when the body’s immune system attacks its own tissues and organs. Image source: CC BY-SA 3.0, via Wikimedia Commons In addition, there have been known cases of individuals, nesting in hollow trees.Did you know that man's best friend can also develop skin lupus? They construct their nests out of crushed or chewed leaves in a large chamber. A typical burrow of this animal is composed of numerous entrances as well as tunnels, which are connected between each other. Eastern chipmunks live in burrows, which they dig themselves. Some chipmunks may be dormant throughout the winter, whereas others display more activity. The duration of torpor depends on populations and individuals. Instead, they regularly wake up from hibernation, occasionally leaving the burrow if it's warm enough. Although they usually hoard food, these animals don't store fat for hibernation period.
In spite of being accomplished climbers, they are terrestrial foragers. Eastern chipmunks are highly territorial, particularly defending areas around their burrows. Periods of increased activity are mid-morning and mid-afternoon.
These rodents are solitary and diurnal animals.
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